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Updated: Mar 15, 2026
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Chiral Separation of Cytotoxic Flavan Derivatives from Daphne giraldii
Fei-Fei Li1, Qian Sun1, Di Wang1
1Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
Abstract:
Twelve new flavan derivatives including four pairs of enantiomers, daphnegiralins A1-A4 (1) and daphnegiralins B1-B4 (2), and two pairs of epimers, daphnegiralins C1/C2 (3) and daphnegiralins D1/D2 (4), were isolated from the stem bark and roots of Daphne giraldii. Their structures were elucidated using spectroscopic analyses, computational approaches, and chemical methods. Separation of the enantiomeric mixtures (1a, 1b, 2a, and 2b) was achieved using chiral HPLC. The compounds were evaluated against a small panel of human cancer cell lines, and 1b-2, 2a, and 2b were cytotoxic against Hep3B human hepatoma cells.
