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Updated: Jan 31, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Therapeutic Potential of Spirooxindoles as Antiviral Agents
Na Ye1, Haiying Chen1, Eric A Wold1
1Chemical Biology Program, Department of Pharmacology and Toxicology, ‡Department of Biochemistry & Molecular Biology, #Sealy Center for Structural Biology & Molecular Biophysics, and ⊥Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch , 301 University Boulevard, Galveston, Texas 77555, United States.
Abstract:
Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low toxicity remain challenging, and obtaining such agents continues to be an active area of therapeutic development. Due to their unique three-dimensional structural features, spirooxindoles have been identified as privileged chemotypes for antiviral drug development. Among them, spiro-pyrazolopyridone oxindoles have been recently reported as potent inhibitors of dengue virus NS4B, leading to the discovery of an orally bioavailable preclinical candidate (R)-44 with excellent in vivo efficacy in a dengue viremia mouse model. This review highlights recent advances in the development of biologically active spirooxindoles for their antiviral potential, primarily focusing on the structure-activity relationships (SARs) and modes of action, as well as future directions to achieve more potent analogues toward a viable antiviral therapy.
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