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Updated: Mar 15, 2026
Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications
Published on: October 5, 2018
Enhanced selective sonosensitizing efficacy of ultrasound-based anticancer treatment by targeted gold nanoparticles
Chiara Brazzale1, Roberto Canaparo2, Luisa Racca2
1Department of Pharmaceutical & Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Aim:
This study investigates cancer targeted gold nanoparticles as ultrasound sensitizers for the treatment of cancer.
Methods:
The ultrasound sensitizer activity of folate-PEG decorated gold nanoparticles (FA-PEG-GNP) has been studied on human cancer cell lines that overexpress folate receptors (KB and HCT-116) and another that does not (MCF7), at two ultrasound energy densities (8 × 10-6 J cm-2 and 8 × 10-5 J cm-2, for 5 min at 1.866 MHz).
Results:
FA-PEG-GNP selectively targeted KB and HCT-116 cells and a remarkable reduction in cancer cell growth was observed upon ultrasound exposure, along with significant reactive oxygen species generation and increase in necrotic cells.
Conclusion:
The combined use of targeting capacity and the ultrasound sensitizing effect, make FA-PEG-GNP promising candidates for the site-specific cancer treatment.
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