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Adverse outcome of coarctation stenting in patients with Turner syndrome

Allard T van den Hoven1, Anthonie L Duijnhouwer2, Andreas Eicken3

  • 1Department of Congenital Cardiology, Erasmus MC, Rotterdam, The Netherlands.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|September 16, 2016
PubMed

Insights

Percutaneous stenting for aortic coarctation in Turner syndrome (TS) patients is effective but carries significant risks. Careful consideration of alternative treatments is advised due to associated morbidity and mortality.

Area of Science:

  • Cardiology
  • Genetics
  • Interventional Radiology

Background:

  • Turner syndrome (TS) affects 1 in 2,500 live-born females.
  • Aortic coarctation is a common cardiovascular complication in TS patients.

Purpose of the Study:

  • To evaluate the outcomes of percutaneous stent angioplasty for aortic coarctation specifically in patients with Turner syndrome.
  • To assess procedural success and adverse events associated with this intervention.

Main Methods:

  • Retrospective, multicenter cohort study including 19 TS patients treated with percutaneous stent implantation.
  • Data collected on procedural strategies, short-term, and long-term adverse events.
  • Qualitative parameters of stent implantation were assessed.

Main Results:

  • Significant increase in coarctation diameter post-intervention (8.0 mm to 15.0 mm, P < 0.001).
  • 15.8% of patients experienced adverse events within 30 days, including dissections and one death.
  • Two additional non-stent-related deaths occurred during long-term follow-up (median 6.5 years).

Conclusions:

  • Percutaneous stenting is an effective treatment for aortic coarctation in TS patients.
  • The procedure is associated with considerable morbidity and mortality.
  • Alternative treatment strategies should be carefully considered alongside percutaneous stenting.
Abstract

Keywords:
BALABMSCONASTECadultsballoon angioplastybare metalcongenital heart diseasestentstenting technique

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