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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

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Study of apoptosis-related interactions in colorectal cancer

Himanshu Arora1, Rehana Qureshi2, M A Rizvi2

  • 1School of Studies in Zoology and Biotechnology, Vikram University, Ujjain, MP, India. himanshu.harora@gmail.com.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|September 16, 2016
PubMed

Insights

Dysregulated apoptosis is key in colorectal cancer. This study identifies crucial molecular interactions involving TP53, miR-143, KRAS, BCL2, and PLK1 as potential drug targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Apoptotic dysfunction is a significant factor in colorectal cancer development.
  • Understanding molecular mechanisms regulating apoptosis is crucial for targeted therapies.

Purpose of the Study:

  • To explore molecular interactions governing apoptotic regulation in colorectal cancer.
  • To identify key genes and microRNAs involved in colorectal cancer pathogenesis.
  • To evaluate the potential of identified molecular players as therapeutic targets.

Main Methods:

  • Utilized enrichment analysis to identify microRNAs targeting TP53 in colon cancer.
  • Performed molecular interaction analysis on shortlisted candidates: TP53, miR-143, KRAS, BCL2, and PLK1.
  • Conducted mutation studies to assess the clinical relevance and drug target suitability of identified candidates.

Main Results:

  • Identified significant molecular interactions between TP53, miR-143, KRAS, BCL2, and PLK1.
  • Mutation analysis indicated that the extent of mutations in these candidates does not significantly impact patient survival.
  • These findings highlight the selected genes and microRNA as promising drug targets.

Conclusions:

  • The study elucidates critical molecular interactions essential for apoptotic regulation in colorectal cancer.
  • TP53, miR-143, KRAS, BCL2, and PLK1 represent viable therapeutic targets for colorectal cancer treatment.
  • Bioinformatics approaches are effective in uncovering complex molecular networks in cancer.
Keywords:
ApoptosisColorectal cancerTP53miRNA

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