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Updated: Mar 15, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
Published on: December 9, 2022
Radiological features of healing in newborn clavicular fractures
Michael Fadell1, Angie Miller2, Laszlo Trefan3
1Children's Hospital Colorado, University of Colorado, 13123 East 16th Avenue, B125, Aurora, CO, 80045, USA. michael.fadell@childrenscolorado.org.
Insights
Infant clavicle fracture healing progresses predictably, with distinct radiological signs appearing at specific times. This evidence aids in dating injuries, crucial for identifying abuse in infants.
Area of Science:
- Pediatric Radiology
- Skeletal Development
- Forensic Imaging
Background:
- Abusive fractures are common in infants.
- Limited research exists on infant fracture healing timelines.
- Radiological evidence is key in evaluating infant injuries.
Purpose of the Study:
- To establish a radiological timetable for fracture healing in infants.
- To describe the sequential appearance of healing features in neonatal clavicle fractures.
- To provide evidence for dating infant fractures.
Main Methods:
- Retrospective cross-sectional time-series study of birth-related clavicle fractures (2006-2013).
- Analysis of 108 digital images from 61 infants.
- Radiologists assessed periosteal reaction, callus, bridging, and remodeling.
Main Results:
- Good to high inter-radiologist agreement (0.60-0.90).
- Healing features observed: periosteal reaction (7 days), callus (11 days), bridging (20 days), remodeling (35 days).
- Peak presence: periosteal reaction (11-42 days), callus (12-61 days), bridging (22-63 days), remodeling (49-59 days).
Conclusions:
- Birth-associated clavicle fractures in infants show a logical healing progression.
- Understanding these timelines aids in assessing injury timing in suspected abuse cases.
- Provides critical evidence for fracture dating in forensic evaluations.
Objectives:
Given the frequency of abusive fractures among infants, and the lack of research and or evidence for the phases of fracture healing seen in this age group, this study aims to describe a timetable of radiological features of fracture healing among infants in the first months of life.
Methods:
We completed a retrospective cross-sectional time-series study of birth-related clavicle fractures from 2006-2013. A total of 108 digital images were available for review from 61 infants. The presence or absence of four features of healing including periosteal reaction, callus formation, bridging callus and remodelling were scored by three radiologists.
Results:
The level of agreement between the radiologists was good to high (0.60-0.90). Features of healing were first seen at 7 days (periosteal reaction), 11 days (callus), 20 days (bridging) and 35 days (remodelling), respectively. The peak periods that each feature was present are as follows: periosteal reaction 11-42 days, callus 12-61 days, bridging 22-63 days and remodelling 49-59 days.
Conclusions:
Birth-associated clavicle fractures in infants follow a logical progression of healing changes. Understanding the expected progression and timing of fracture healing may be helpful as it pertains to the timing of injury in cases of abuse in infants.
Key Points:
• Large study describing the time frames of fracture healing in young infants. • Features of fracture healing develop in a logical progression. • Evidence provided for determining fractures are consistent with a proposed time frame. • It is of critical importance to have sound evidence for the dating of fractures.
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