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Author Spotlight: Advancements in Multichannel Extracellular Recording for Studying Neuronal Activity in Freely Moving Mice
Published on: May 26, 2023
Artefactual origin of biphasic cortical spike-LFP correlation
Michael Okun1,2,3,4,5
1Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, LE1 9HN, UK. mo178@le.ac.uk.
Abstract:
Electrophysiological data acquisition systems introduce various distortions into the signals they record. While such distortions were discussed previously, their effects are often not appreciated. Here I show that the biphasic shape of cortical spike-triggered LFP average (stLFP), reported in multiple studies, is likely an artefact introduced by high-pass filter of the neural data acquisition system when the actual stLFP has a single trough around the zero lag.

