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Dialyzability of Faropenem in Infected Patients on Chronic Hemodialysis

Gohki Hasegawa1, Shuichi Tsuruoka1, Kentaro Ushijima1

  • 1Department of Clinical Pharmacology, Jichi Medical University, Tochigi, Japan.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|September 16, 2016
PubMed

Insights

Faropenem (FRPM) shows low dialyzability in hemodialysis patients, with minimal drug removal during sessions. This suggests a standard 200mg twice-daily dose may be effective and safe for treating infections in these patients.

Area of Science:

  • Pharmacokinetics
  • Infectious Diseases
  • Nephrology

Background:

  • Antibiotic therapy is crucial for managing infections in hemodialysis patients.
  • Understanding drug dialyzability is essential for optimizing treatment in patients with kidney failure.

Purpose of the Study:

  • To evaluate the dialyzability and pharmacokinetic profile of the oral penem antibiotic, faropenem (FRPM), in hemodialysis patients.
  • To determine the safety and efficacy of FRPM in treating infections in this population.

Main Methods:

  • Eight hemodialysis patients received oral faropenem (200 mg) every 12 hours.
  • Blood samples were collected before and after hemodialysis sessions to measure plasma FRPM concentrations.
  • Dialyzer clearance, elimination fraction, and drug removal percentage were calculated.

Main Results:

  • Plasma FRPM concentrations remained above minimal inhibitory concentrations throughout the study.
  • Dialyzer clearance was 14.9 ± 6.8 mL/min/m², and the elimination fraction was 20.4 ± 9.9%.
  • Only about 2% of FRPM was removed during a single hemodialysis session, indicating low dialyzability.

Conclusions:

  • Faropenem exhibits low dialyzability in hemodialysis patients, with minimal drug removal during dialysis.
  • FRPM treatment improved infection-related symptoms, white blood cell count, and C-reactive protein levels without adverse effects.
  • A dosage regimen of 200 mg twice daily appears effective and safe, potentially negating the need for additional dosing post-hemodialysis.
Keywords:
DialyzabilityFaropenemHemodialysisInfection

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