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IgG4-related Disease Involving Multiple Organs with Elevated Serum Interleukin-6 Levels
Tsukasa Ikeura1, Shunsuke Horitani, Masataka Masuda
1The Third Department of Internal Medicine, Kansai Medical University, Japan.
Internal Medicine (Tokyo, Japan)
|September 16, 2016
Summary
This case report details a patient diagnosed with IgG4-related disease, highlighting the diagnostic challenges due to overlapping symptoms with multicentric Castleman disease.
Area of Science:
- Immunology
- Gastroenterology
- Pathology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition.
- Multicentric Castleman disease (MCD) is a lymphoproliferative disorder.
Observation:
- A 63-year-old woman presented with gallbladder wall thickening, hepatomegaly, lymphadenopathy, fever, and leg edema.
- Laboratory findings included elevated serum IgG4, anemia, hypoalbuminemia, and elevated interleukin-6 and C-reactive protein.
Findings:
- The patient met diagnostic criteria for IgG4-related disease.
- Clinical and laboratory features mimicked multicentric Castleman disease.
Implications:
- Differentiating IgG4-RD from MCD can be challenging due to overlapping presentations.
- Accurate diagnosis is crucial for appropriate patient management and treatment strategies.
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