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Related Experiment Videos

Compartmentalizing chemomechanical transduction in the ejecting heart.

I B Krukenkamp1, N A Silverman, S Levitsky

  • 1Department of Surgery, University of Illinois College of Medicine, Chicago.

Surgery
|August 1, 1989
PubMed
Summary

Calcium chloride enhances external work efficiency but increases myocardial oxygen consumption. Ischemia-reperfusion decreases external work efficiency and oxygen needs, impacting cardiac energy transfer.

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Area of Science:

  • Cardiovascular Physiology
  • Cardiac Energetics
  • Myocardial Metabolism

Background:

  • Ventricular contraction generates energy partitioned into external work and internal work.
  • Myocardial oxygen consumption (MVO2) is a key indicator of cardiac energetic efficiency.
  • Understanding energy transfer efficiency is crucial for managing cardiac conditions.

Purpose of the Study:

  • To investigate the effects of altered contractility on the efficiency of energy transfer from ventricular pressure-volume area (PVA) to external work (EW) and internal work (IW).
  • To determine the impact of contractility changes on myocardial oxygen consumption (MVO2) at zero PVA.
  • To evaluate the efficacy of a novel model for modulating cardiac energetic derangements.

Main Methods:

  • Utilized a right heart bypass model in isolated hearts.

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  • Assessed PVA, EW, and IW efficiencies before and after interventions.
  • Administered calcium chloride (CaCl2) to augment contractility and induced ischemia-reperfusion to depress contractility.
  • Measured MVO2 at zero PVA to assess basal and contractile energy demands.

    • Main Results:

    • Calcium chloride augmentation increased EW efficiency (64% to 81%) and decreased IW efficiency (36% to 19%), with significantly elevated MVO2 for basal metabolism and fiber shortening.
    • Ischemia-reperfusion insult reversed these efficiencies, decreasing EW efficiency (73% to 49%) and increasing IW efficiency (27% to 51%), with reduced MVO2 for fiber shortening.
    • These changes correlated with the augmented or depressed inotropic states, respectively.

    Conclusions:

    • Altered myocardial contractility significantly impacts the partitioning of energy between external and internal work and influences MVO2.
    • The observed changes in efficiency and MVO2 provide insights into cardiac energetic derangements.
    • This study introduces a model for compartmentalized chemomechanical transduction, potentially aiding in the management of cardiac energetic issues in clinical settings.