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A Mouse Model of Fluorescent Protein-expressing Disseminated Peritoneal Lymphoma for Fluorescence-guided Surgery
Takuro Matsumoto1, Atsushi Suetsugu2, Kosuke Hasegawa1
1Gifu University Graduate School of Medicine, Gifu, Japan.
Background:
Fluorescence-guided surgery (FGS) of tumors is an area of intense development. Peritoneally-disseminated cancer, however, represents a difficult surgical challenge.
Materials And Methods:
To help meet this challenge, EL4 mouse T-cell lymphoma cells expressing red fluorescent protein (RFP) were injected intraperitoneally in nude mice.
Results:
Two weeks after injection of EL4-RFP cells, established peritoneally-disseminated tumors were observed. FGS was performed using a hand-held portable fluorescence imaging system (Dino-Lite). FGS enabled detection of very small peritoneal disseminated tumors and completely resected them in contrast to bright-light which only partially detected the tumors.
Conclusion:
The present report indicates the feasibility of FGS of peritoneally-disseminated cancer.
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