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Correlation Between Poor Prognosis and Lower TPPP Gene Expression in Hepatocellular Carcinoma
Yoshikuni Inokawa1, Fuminori Sonohara1, Mitsuro Kanda2
1Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan Department of Surgery, Aichi Gakuin University School of Dentistry, Nagoya, Japan.
Background/Aim:
Post-resection recurrence of hepatocellular carcinoma (HCC) tends to derive from multicentric origins, which indicates that the background liver microenvironment affects carcinogenesis.
Materials And Methods:
We obtained control liver samples [super normal (SN)] from 11 patients with secondary metastatic liver malignancies and used expression and methylation arrays to compare them with non-cancerous liver tissue from a patient with typical HCC with chronic hepatitis C (corresponding normal (CN)].
Results:
The expression array showed that gene expression of tubulin polymerization-promoting protein (TPPP) was lower in CN compared with SN. The methylation array showed a greater TPPP methylation index for CN than for SN. Transcripts of TPPP differed significantly among SN (n=11), CN (n=179), and tumor tissue of HCC (n=179) (median of 116, 4.60, and 2.63, respectively, p<0.001). Multivariate analysis showed lower TPPP expression in tumor than in normal tissue (ratio <0.3, n=57) to independently predict poor overall survival (p=0.031).
Conclusion:
Significantly lower TPPP expression was found in HCC and CN tissue compared to SN and indicated poor prognosis.
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