Related Experiment Video
Updated: Mar 15, 2026
09:18
Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
Published on: February 3, 2026
788
Prediction of KRAS Mutation in Rectal Cancer Using MRI
Yu Ri Shin1, Kyung Ah Kim2, Soyoung Im3
1Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Anticancer Research
|September 16, 2016
Summary
Magnetic resonance imaging (MRI) can predict Kirsten-ras (KRAS) mutations in rectal cancer patients. Specific MRI findings like tumor shape and size correlate with KRAS mutation status, aiding in treatment decisions.
Area of Science:
- Oncology
- Radiology
- Genetics
Background:
- Rectal cancer prognosis and treatment are influenced by Kirsten-ras (KRAS) mutations.
- Non-invasive methods to predict KRAS mutation status are valuable for treatment planning.
Purpose of the Study:
- To identify magnetic resonance imaging (MRI) predictors of KRAS mutations in rectal cancer.
- To correlate specific MRI features with the presence of KRAS mutations.
Main Methods:
- Retrospective analysis of 275 rectal cancer patients.
- Pretreatment rectal MRI and post-surgery KRAS mutation evaluation.
- Assessment of MRI findings including tumor dimensions and pattern by two independent reviewers.
Main Results:
- KRAS mutations were found in 38.9% of patients.
- KRAS mutations significantly correlated with N stage, polypoid tumor pattern, axial tumor length, and the ratio of axial to longitudinal dimensions.
- Higher mutation frequency observed in N2 stage (53.70%) and polypoid tumors (59.09%).
Conclusions:
- MRI can predict KRAS mutations in rectal cancer.
- Tumor characteristics such as N stage, polypoid morphology, and specific dimensional ratios on MRI are associated with KRAS mutations.
Related Concept Videos
01:24Magnetic Resonance Imaging
10.1K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.1K
02:38The Ras Gene
7.4K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
Ras is a...
7.4K
01:27Imaging Studies IV: Magnetic Resonance Imaging
348
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
348