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Lipid Profile in Cardiac Syndrome X: Association with Helicobacter pylori
Yousef Rasmi1, Javad Zeynalzadeh2, Alireza Shirpoor3
1Professor, Cellular and Molecular Research Center, Urmia University of Medical Sciences , Urmia, Iran; Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran .
Insights
Helicobacter pylori infection and elevated lipid profiles are linked to Cardiac Syndrome X (CSX). Plasma lipid disorders play a significant role in CSX development, highlighting potential therapeutic targets.
Area of Science:
- Cardiology
- Infectious Diseases
- Clinical Biochemistry
Background:
- Chronic inflammation from Helicobacter pylori (H. pylori) infection is implicated in Cardiac Syndrome X (CSX).
- Bacterial infections, including H. pylori, may influence blood lipid levels.
Purpose of the Study:
- To investigate the association between H. pylori infection and lipid profile levels in patients with CSX.
Main Methods:
- Eighty-eight CSX patients and 97 healthy controls were analyzed.
- Lipid profile parameters (Total Cholesterol, Triglycerides, Lipoprotein A, LDL, HDL, Apolipoprotein A1, Apolipoprotein B) were measured.
- H. pylori IgG antibodies were detected using ELISA.
Main Results:
- CSX patients exhibited significantly higher levels of Total Cholesterol, Lipoprotein A, LDL, Apolipoprotein A1, and Apolipoprotein B compared to controls.
- No significant differences in these lipid parameters were observed between H. pylori positive and negative individuals within either the CSX or control groups.
Conclusions:
- Elevated plasma lipid levels and H. pylori infection are associated with CSX.
- Plasma lipid disorders appear to be a significant factor in the pathogenesis of CSX.
Introduction:
Chronic inflammation caused by Helicobacter pylori (H.pylori) infection has a pathogenic role in Cardiac Syndrome X (CSX). In addition, it has shown that bacterial infection may affect blood lipids.
Aim:
To assess if H.pylori affects the level of lipid profile in CSX.
Materials And Methods:
Eighty-eight CSX patients and 97 healthy controls were enrolled. The Total Cholesterol (TC), Triglyceride (TG), Lipoprotein A (LP{A}), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Apoprotein A1 (APOA1), and Apoprotein B (APOB) was estimated colorimetrically. In addition, the presence of IgG antibody to H.pylori was tested in plasma samples by using enzyme linked immunosorbent assay method.
Results:
TC, LP{A}, LDL, APOA1 and APOB levels in CSX group were significantly higher than those of the control group (p<0.05). But, these parameters in H.pylori positive and H.pylori negative, among CSX and control groups were not significant.
Conclusion:
Increased plasma level of lipid profile and H.pylori infection were associated with CSX; it seems that plasma lipid disorders have a significant role in the development of CSX.
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