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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
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Pregnancy with Pemphigoid Gestationis: A Rare Entity
Anshuja Singla1, Sneha Shree2, Sumita Mehta3
1Assistant Professor, Department of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital , Delhi, India .
Journal of Clinical and Diagnostic Research : JCDR
|September 16, 2016
Summary
Pemphigoid Gestationis (PG) is a rare autoimmune blistering disease affecting pregnant women. This case highlights its presentation and management, including pregnancy termination due to hypertension and stillbirth.
Area of Science:
- Dermatology
- Obstetrics
- Immunology
Background:
- Pemphigoid Gestationis (PG) is a rare autoimmune blistering disease affecting approximately 1 in 50,000 pregnancies.
- It typically manifests in the second or third trimester and can recur with increased severity in subsequent pregnancies.
- Direct Immunofluorescence (DIF) on skin biopsy is the gold standard for diagnosing PG.
Observation:
- A 24-year-old pregnant female presented at 6 months gestation with elevated blood pressure.
- Physical examination revealed fresh bullous lesions and healed scars on her abdomen and limbs.
- Pregnancy termination was necessitated by severe hypertension, resulting in a stillbirth weighing 750g.
Findings:
- The patient experienced no postpartum exacerbation of PG.
- She was discharged in stable condition on prednisolone treatment.
- The case underscores the potential complications of PG, including adverse pregnancy outcomes.
Implications:
- This case emphasizes the importance of vigilant monitoring and management of Pemphigoid Gestationis during pregnancy.
- Early diagnosis and intervention are crucial for managing maternal complications and potential fetal risks.
- Further research into PG's impact on pregnancy outcomes and optimal treatment strategies is warranted.
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