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Updated: Mar 15, 2026

Affinity-based Isolation of Tagged Nuclei from Drosophila Tissues for Gene Expression Analysis
Published on: March 25, 2014
Revisiting von Restorff's early isolation effect
Stephen R Schmidt1, Constance R Schmidt2
1Psychology Department, Middle Tennessee State University, Box 87, Murfreesboro, TN, 37132, USA. Stephen.Schmidt@mtsu.edu.
Abstract:
An item that is conceptually or physically different from other items in a series is often remembered well. This isolation effect has been found independent of the position of the isolated item in the list, suggesting that special attention to or processing of the isolated item is not a necessary precondition of the effect. Three experiments are reported that challenge this conclusion. In Experiment 1a, we compared memory for conceptually isolated items to memory for the same items in unrelated and homogeneous lists. Under moderately distracting conditions, isolation effects were observed with midlist but not with early isolates. In fact, early isolation impaired memory for the conceptually distinct items relative to the same items in homogeneous lists. Experiment 1b replicated this memory impairment for early conceptual isolates and extended it to nondistracting conditions. In Experiment 2, we focused on early isolation, manipulating the type of isolation and whether or not participants performed judgments of learning (JOLs). An early isolation effect was observed for numbers isolated in lists of words (and vice versa), but not for conceptual isolates. Performing the JOL task reduced the size of the early isolation effect. These results suggest that number/word stimulus contrasts are coded automatically and support an isolation effect independent of list position. However, conceptual contrasts require relational processing and will only support an early isolation effect when such processing occurs. The results of Experiments 1a, 1b, and 2 suggest that attentional resources during list presentation and a favorable retrieval environment combine to support good memory for distinctive events.
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