Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.7K

The research and development on the antioxidants in prevention of diabetic complications

Mohammad Rahimi-Madiseh1, Afsaneh Malekpour-Tehrani2, Mahmoud Bahmani3

  • 1Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Asian Pacific Journal of Tropical Medicine
|September 17, 2016
PubMed

Insights

Oxidative stress contributes to type 2 diabetes complications. While antioxidants show promise, clinical evidence for single or combined antioxidant supplements preventing diabetic damage remains unclear.

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Oxidative Stress Research

Background:

  • Diabetes mellitus complications, including microvascular and macrovascular disorders, are leading causes of morbidity and mortality.
  • Hyperglycemia exacerbates oxidative stress and lipid peroxidation, implicating free radicals in diabetic pathogenesis.
  • Oxidative stress is implicated in various conditions like kidney damage, atherosclerosis, and cardiovascular disease.

Purpose of the Study:

  • To review the role of oxidative stress in microvascular complications of type 2 diabetes mellitus.
  • To examine current findings on antioxidants in preventing and treating diabetes and its complications (retinopathy, nephropathy, neuropathy).

Main Methods:

  • Literature review focusing on oxidative stress mechanisms in diabetic complications.
  • Analysis of studies investigating the efficacy of single and combination antioxidants.

Main Results:

  • Clinical trials have not definitively confirmed the substantial impact of free radicals or antioxidant supplementation on diabetic damage.
  • Antioxidants found in natural food sources (fruits, vegetables, grains) may aid in preventing diabetes complications.
  • Evidence for the protective effects of single antioxidants (e.g., vitamin E, vitamin C) is limited.
  • Findings on combination antioxidants are complex and not fully elucidated.

Conclusions:

  • Oxidative stress plays a significant role in the microvascular complications of type 2 diabetes mellitus.
  • Further research is needed to clarify the role and efficacy of various antioxidants in managing diabetes and its associated complications.
Keywords:
Diabetes complicationsDiabetic nephropathyNatural antioxidantsNephropathyNeuropathyRetinopathy

More Related Videos

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.7K
Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

715

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.6K
Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
796
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.3K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.1K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.2K
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
3.3K