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Chronic diarrhoea: a methodologic basis for its apparent heterogeneity.

B Stanton1, J D Clemens

  • 1MCH Specialist, World Bank, Bangladesh.

Tropical and Geographical Medicine
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

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Methodological inconsistencies, including undefined terms like 'diarrhoea' and 'chronic', contribute to varied findings in chronic diarrhoea research. Standardized definitions are crucial for reliable etiologic and epidemiologic studies.

Area of Science:

  • Gastroenterology
  • Epidemiology
  • Medical Research Methodology

Background:

  • Etiologic and epidemiologic patterns of chronic diarrhoea show extensive variation across studies.
  • This heterogeneity may stem from the disease's complexity and, significantly, from methodological inconsistencies in research.

Purpose of the Study:

  • To assess the comparability of age ranges and the use of standardized definitions for 'chronic' and 'diarrhoea' in chronic diarrhoea research.
  • To highlight the impact of inconsistent methodologies on research findings.

Main Methods:

  • A systematic review of 44 research papers on chronic diarrhoea was conducted.
  • Papers were analyzed for the age range of study subjects and the presence and consistency of definitions for 'chronic' and 'diarrhoea'.

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Main Results:

  • Wide variation in age ranges was observed, from two weeks to 91 years.
  • Definitions for 'diarrhoea' were absent in 30% of studies and 'chronic' in 25%.
  • Among studies providing definitions, significant inconsistencies were found: four different criteria for 'diarrhoea' and eight for 'chronic'.

Conclusions:

  • Lack of standardized definitions for key terms like 'diarrhoea' and 'chronic' significantly impacts the comparability and reliability of chronic diarrhoea research.
  • Inconsistent age ranges and definitions contribute to the heterogeneity observed in the etiologic and epidemiologic patterns of chronic diarrhoea.
  • The adoption of standardized methodologies is essential for advancing the understanding of chronic diarrhoea.