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Updated: Mar 15, 2026

Monitoring Stub1-Mediated Pexophagy
Published on: May 12, 2023
Epigenetic regulation of peroxiredoxins: Implications in the pathogenesis of cancer
Suet-Hui Ow1, Pei-Jou Chua1, Boon-Huat Bay1
1Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore.
Abstract:
Peroxiredoxin I to VI (PRX I-VI), a family of highly conserved antioxidants, has been implicated in numerous diseases. There have been reports that PRXs are expressed aberrantly in a variety of tumors, implying that they could play an important role in carcinogenesis. Epigenetic mechanisms such as DNA methylation, histone modifications, and microRNAs have been reported to modulate expression of PRXs. In addition, the use of epigenetic regulators, such as histone deacetylases, has been demonstrated to restore PRX to normal levels, indicating that the reversible nature of epigenetics can be exploited for future treatments.
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