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Acute airsacculitis in turkeys inoculated with Pasteurella multocida
1Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh.
Veterinary Pathology
|May 1, 1989
Summary
Pasteurella multocida rapidly infects turkey air sacs, causing inflammation and cell migration. This infection can serve as a pathway for bacteria to enter the bloodstream, impacting turkey health.
Area of Science:
- Avian Pathology
- Bacteriology
- Immunology
Background:
- Pasteurella multocida is a significant avian pathogen.
- Understanding the initial host response to P. multocida infection is crucial for disease management in poultry.
Purpose of the Study:
- To investigate the early pathogenesis of Pasteurella multocida in turkey air sacs.
- To determine the route of P. multocida entry into the systemic circulation.
Main Methods:
- Inoculation of turkeys' caudal thoracic air sacs with P. multocida.
- Examination of air sac tissues and lavage fluids from 0 to 6 hours post-inoculation.
- Microscopic and ultrastructural analysis of cellular responses and bacterial presence.
Main Results:
- Rapid and intense air sac inflammation with heterophil exudation occurred.
- P. multocida was detected in blood by 3 hours post-inoculation.
- Heterophils migrated into air sac lumens, and epithelial damage facilitated bacterial entry.
Conclusions:
- Turkey air sacs serve as a portal of entry for P. multocida into the systemic circulation.
- Epithelial damage in the air sac is a likely mechanism for bacterial translocation.
- Early inflammatory responses involve significant heterophil infiltration.