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Related Experiment Video

Updated: Mar 15, 2026

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
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A nomogram predicting contralateral central neck lymph node metastasis for papillary thyroid carcinoma.

Hu Hei1, Yongping Song2, Jianwu Qin3

  • 1Department of Thyroid and Neck, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

Journal of Surgical Oncology
|September 17, 2016
PubMed
Summary

A new nomogram helps estimate the risk of papillary thyroid carcinoma (PTC) metastasis to the opposite side of the neck. This tool aids surgeons in deciding whether to perform contralateral central neck dissection (CCND) for PTC patients.

Keywords:
contralateral central neck compartmentlymph node metastasisnomogrampapillary thyroid carcinoma

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Thyroid Cancer Research

Background:

  • Central compartment neck dissection (CCND) is standard for papillary thyroid carcinoma (PTC).
  • The necessity of contralateral CCND for unilateral PTC is not well-defined.
  • Accurate risk assessment for contralateral central neck metastasis (CNM) is crucial for personalized treatment.

Purpose of the Study:

  • To develop and validate a predictive model for contralateral central neck metastasis (CNM) in unilateral papillary thyroid carcinoma (PTC).
  • To aid in the individualized decision-making process for contralateral central neck dissection (CCND).

Main Methods:

  • Retrospective analysis of 142 patients who underwent bilateral CCND for unilateral PTC.
  • Development of a nomogram using multivariate logistic regression to predict CNM risk.
  • Internal validation of the nomogram using bootstrap resampling.

Main Results:

  • The developed nomogram demonstrated good calibration and discrimination (concordance index of 0.834).
  • Key predictors for contralateral CNM included tumor size, ipsilateral lymph node positivity, and extranodal extension.
  • The nomogram provides an individualized risk estimation for contralateral metastasis.

Conclusions:

  • A validated nomogram integrating tumor size, lymph node status, and extranodal extension can predict contralateral CNM risk in unilateral PTC.
  • This tool supports personalized treatment strategies, potentially reducing overtreatment and undertreatment of PTC patients.
  • The nomogram facilitates informed decisions regarding contralateral central neck dissection (CCND).