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Related Concept Videos

Thermosensation01:43

Thermosensation

34.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Related Experiment Video

Updated: Mar 15, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

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TRPM8 and Migraine.

Greg Dussor1, Yu-Qing Cao2

  • 1School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA. gregory.dussor1@utdallas.edu.

Headache
|September 17, 2016
PubMed
Summary
This summary is machine-generated.

The transient receptor-potential M8 (TRPM8) channel in the meninges may contribute to migraine. Both TRPM8 agonists and antagonists could be potential therapeutics, suggesting TRPM8 as a target for personalized migraine medicine.

Keywords:
TRPduraicilinmeningesmentholtrigeminal

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Migraine is a disabling neurological disease with limited treatment efficacy.
  • Genome-wide association studies (GWAS) link the transient receptor-potential M8 (TRPM8) channel to migraine.
  • TRPM8, a cold and pain sensor, is expressed on sensory neurons, including those innervating the meninges.

Purpose of the Study:

  • To review the anatomical and physiological roles of meningeal TRPM8 in migraine.
  • To explore TRPM8 as a potential therapeutic target for migraine treatment.

Main Methods:

  • Review of existing literature on TRPM8 function, expression, and involvement in pain pathways.
  • Analysis of preclinical studies investigating TRPM8 activation in headache models.
  • Discussion of potential endogenous ligands and activation mechanisms in the meninges.

Main Results:

  • TRPM8 is expressed on meningeal sensory afferents, with potential developmental influences on migraine contribution.
  • Meningeal TRPM8 activation by exogenous agonists can paradoxically cause or alleviate headache behaviors.
  • TRPM8's role in migraine may depend on the specific trigger and concurrent stimuli.

Conclusions:

  • TRPM8 represents a novel target for migraine therapy.
  • Both TRPM8 agonists and antagonists may offer therapeutic benefits, depending on individual patient triggers.
  • TRPM8 targeting holds promise for personalized medicine approaches in migraine treatment.