[Predictors of epilepsy in children after ischemic stroke]
O A Lvova1, L V Shalkevich2, A N Dron3
1The First President of Russia B.N. Yeltsin, Ural Federal University, Yekaterinburg, Russia.
Insights
Identifying predictors of epilepsy after childhood ischemic stroke is crucial. Seizure type, generalization, and specific EEG patterns are key indicators for predicting post-stroke epilepsy in children.
Area of Science:
- Pediatric Neurology
- Stroke Research
- Epilepsy Studies
Background:
- Ischemic stroke in children can lead to long-term neurological deficits.
- Symptomatic epilepsy is a significant complication following pediatric ischemic stroke.
- Identifying predictive factors is essential for early intervention and management.
Purpose of the Study:
- To identify clinical and instrumental predictors of symptomatic epilepsy in children after an ischemic stroke.
- To stratify risk factors for the development of epilepsy post-stroke.
Main Methods:
- A cohort of 136 pediatric patients (0-15 years) diagnosed with ischemic stroke was studied.
- Patients were categorized into post-stroke epilepsy (n=22) and control (n=114) groups.
- Predictors were analyzed using electroencephalography (EEG) and acute-stage convulsive syndrome characteristics.
Main Results:
- Generalized seizure types and focal seizures with secondary generalization were identified as predictors.
- Epileptiform activity, particularly focal epileptiform discharges, indicated increased risk.
- Specific EEG findings like slow wave background activity and disorganized activity in conjunction with generalized seizures were significant.
Conclusions:
- Generalized seizures, focal seizures with secondary generalization, and specific EEG abnormalities are prognostic criteria for epilepsy after pediatric ischemic stroke.
- EEG findings, including epileptiform activity and background abnormalities, are vital for predicting epilepsy risk.
Aim:
To determine clinical/instrumental predictors of symptomatic epilepsy after ischemic stroke in children.
Material And Methods:
One hundred and thirty-six patients, aged 0-15 years, with the diagnosis of ischemic stroke (ICD-10 I63.0-I63.9) were examined. The duration of the study was 18 months - 12 years. Patients were stratified into post-stroke (n=22) and control (n=114) groups, the latter included patients without epilepsy regardless of the presence of convulsive seizures in the acute stage of stroke. Predictors were determined based on EEG and characteristics of convulsive syndrome in the acute stage of stroke.
Results And Conclusion:
The following prognostic criteria were found: generalized type of seizures, focal type of seizures with secondary generalization, epileptiform (peak and/or peak-wave) activity, focal character of epileptiform activity, generalized type of seizures in the combination with slow wave background activity on EEG, generalized type of seizures in the combination with slow wave activity and disorganized activity on EEG.
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