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Renomedullary Interstitial Cell Tumors: Pathologic Features and Clinical Correlations
Anna Caliò1, Kathleen A Warfel, John N Eble
1*Department of Pathology, University of Verona, Verona, Italy †Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.
The American Journal of Surgical Pathology
|September 17, 2016
Summary
Renomedullary interstitial cell tumors are common kidney findings. These tumors originate from interstitial cells, with morphology changing with age and size, showing decreased cellularity and collagen deposition in older patients.
Area of Science:
- Nephrology
- Pathology
- Oncology
Background:
- Renomedullary interstitial cell tumors are frequently found incidentally in kidney specimens.
- Their specific morphology and pathogenesis remain poorly understood despite their prevalence.
Purpose of the Study:
- To investigate the morphology and pathogenesis of renomedullary interstitial cell tumors.
- To identify factors influencing tumor characteristics such as cellularity, tubular presence, and material deposition.
Main Methods:
- Histological examination of kidney sections from 402 unselected autopsies.
- Analysis of 421 renomedullary interstitial cell tumors from 150 patients.
- Correlation of tumor features with patient demographics and clinical data.
Main Results:
- 37% of patients had these tumors, with an average of 3 tumors per patient.
- Tumor characteristics varied with age and size: younger patients and smaller tumors had higher cellularity and entrapped tubules.
- Older patients and larger tumors showed decreased cellularity, peripheral or absent tubules, and deposition of collagen type III.
Conclusions:
- Renomedullary interstitial cell tumors likely arise from interstitial cell proliferation between medullary tubules.
- Tumor evolution involves decreased cellularity, collagen III deposition, and tubule loss as they grow.
- Age and tumor size are key factors influencing the observed morphological changes.
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