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Related Experiment Video

Updated: Mar 15, 2026

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation
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A Mouse Model of Furosemide-Induced Overactive Bladder.

Michael S Saporito1, Eva Zuvich2, Amy DiCamillo2

  • 1Shaw's Bridge Advisors, LLC, West Chester, Pennsylvania.

Current Protocols in Pharmacology
|September 17, 2016
PubMed
Summary

This study presents a mouse model for overactive bladder and incontinence using diuretic-induced urination. The automated system accurately detects treatments for overactive bladder, regardless of their mechanism of action.

Keywords:
GABAB receptorbaclofenmicturitionmuscarinic receptoroxybutyninurinary incontinence

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Area of Science:

  • Pharmacology
  • Urology
  • Animal Models

Background:

  • Overactive bladder (OAB) and urinary incontinence are significant health concerns.
  • Current treatments for OAB often have limitations or side effects.
  • A reliable animal model is crucial for developing new therapeutic agents.

Purpose of the Study:

  • To detail a novel mouse model for overactive bladder and urinary incontinence.
  • To validate a sensitive, automated method for measuring urinary function.
  • To assess the model's predictive value for identifying potential OAB treatments.

Main Methods:

  • Induction of urination in mice via diuretic stress.
  • Utilizing a highly sensitive, automated urine capturing system.
  • Measurement of key urinary parameters: latency, frequency, and void volume.

Main Results:

  • The automated system effectively captured and measured urinary parameters.
  • The model successfully detected the effects of an anti-muscarinic drug.
  • The model also identified effective non-cholinergic agents, demonstrating broad applicability.

Conclusions:

  • This diuretic stress-induced urination model is a valuable tool for OAB research.
  • The automated measurement system provides reliable and sensitive data.
  • The model demonstrates predictive value for clinical efficacy of OAB treatments, irrespective of their pharmacological target.