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A Mouse Model of Furosemide-Induced Overactive Bladder
Michael S Saporito1, Eva Zuvich2, Amy DiCamillo2
1Shaw's Bridge Advisors, LLC, West Chester, Pennsylvania.
Current Protocols in Pharmacology
|September 17, 2016
Summary
This study presents a mouse model for overactive bladder and incontinence using diuretic-induced urination. The automated system accurately detects treatments for overactive bladder, regardless of their mechanism of action.
Area of Science:
- Pharmacology
- Urology
- Animal Models
Background:
- Overactive bladder (OAB) and urinary incontinence are significant health concerns.
- Current treatments for OAB often have limitations or side effects.
- A reliable animal model is crucial for developing new therapeutic agents.
Purpose of the Study:
- To detail a novel mouse model for overactive bladder and urinary incontinence.
- To validate a sensitive, automated method for measuring urinary function.
- To assess the model's predictive value for identifying potential OAB treatments.
Main Methods:
- Induction of urination in mice via diuretic stress.
- Utilizing a highly sensitive, automated urine capturing system.
- Measurement of key urinary parameters: latency, frequency, and void volume.
Main Results:
- The automated system effectively captured and measured urinary parameters.
- The model successfully detected the effects of an anti-muscarinic drug.
- The model also identified effective non-cholinergic agents, demonstrating broad applicability.
Conclusions:
- This diuretic stress-induced urination model is a valuable tool for OAB research.
- The automated measurement system provides reliable and sensitive data.
- The model demonstrates predictive value for clinical efficacy of OAB treatments, irrespective of their pharmacological target.
