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[Physical training in chronic heart failure: pathophysiology and clinical evolution]
Eduardo Rivas Estany1, Susana Hernández García2
1Centro de Rehabilitación del Instituto de Cardiología y Cirugía Cardiovascular, La Habana, Cuba. Address: Calle 17 702, Vedado, La Habana, Cuba.
Medwave
|September 17, 2016
Summary
Chronic heart failure affects millions globally. Recent advancements include new medications like angiotensin receptor-neprilysin inhibitors and a reassessment of exercise
Area of Science:
- Cardiology and Internal Medicine
- Pharmacology and Therapeutics
- Exercise Physiology
Background:
- Chronic heart failure is a major global health issue affecting 23 million people worldwide.
- Increasing longevity leads to more co-morbidities, complicating heart failure management.
- Treatment paradigms for heart failure have evolved significantly over recent decades.
Purpose of the Study:
- To review the evolution of heart failure treatments, focusing on pharmacological advancements.
- To explore the role of exercise training in heart failure management and its impact on clinical outcomes.
- To highlight the significance of novel therapeutic agents in reducing heart failure mortality and morbidity.
Main Methods:
- Literature review of pharmacological interventions for chronic heart failure.
- Analysis of pathophysiological mechanisms linking physical activity and heart failure.
- Examination of clinical outcomes, morbidity, and mortality data in heart failure patients undergoing exercise training.
Main Results:
- Shift from sympathomimetic drugs to beta-blocking agents represents a conceptual change in heart failure interpretation.
- Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have significantly reduced heart failure mortality and morbidity.
- Angiotensin receptor-neprilysin inhibitor (LCZ696) demonstrates further reductions in mortality and morbidity with fewer side effects.
Conclusions:
- Novel pharmacotherapies, including LCZ696, offer significant hope for improved heart failure treatment.
- Systematic physical exercise is an integral part of heart failure management, influencing clinical outcomes.
- A comprehensive approach combining advanced pharmacological treatments and tailored exercise programs is crucial for managing chronic heart failure.
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