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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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T cells in Systemic Lupus Erythematosus.
Abel Suárez-Fueyo1, Sean J Bradley1, George C Tsokos1
1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Current Opinion in Immunology
|September 17, 2016
Summary
Systemic Lupus Erythematosus (SLE) involves genetic and environmental factors disrupting T cell responses. Understanding these T cell changes is key for new therapies and patient classification.
Area of Science:
- Immunology
- Genetics
- Epigenetics
Background:
- Systemic Lupus Erythematosus (SLE) is an autoimmune disease with complex origins.
- Genetic, epigenetic, and environmental factors contribute to SLE pathogenesis.
- Altered T cell function is a hallmark of SLE.
Purpose of the Study:
- To elucidate the specific T cell alterations in SLE.
- To understand the origins of these aberrant T cell responses.
- To identify potential therapeutic targets and improve patient classification.
Main Methods:
- Analysis of T cell polymorphisms and epigenetic modifications.
- Assessment of gene expression and molecular function in T cells.
- Investigation of metabolic and functional T cell alterations.
Main Results:
- SLE is characterized by abnormal T cell responses due to genetic and epigenetic factors.
- Metabolic and functional T cell changes lead to tolerance failures.
- Differentiation bias towards pro-inflammatory and B cell-helper T cells occurs, alongside accumulation of disease-promoting memory T cells.
Conclusions:
- Understanding T cell alterations in SLE is crucial.
- These insights can lead to improved patient stratification.
- New therapeutic strategies for SLE can be developed based on T cell dysfunction.
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