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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.9K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.9K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.8K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Related Experiment Video

Updated: Mar 15, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

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Autoimmunity in common variable immunodeficiency: epidemiology, pathophysiology and management.

Gholamreza Azizi1,2,3, Hassan Abolhassani2,4, Mohammad Hosein Asgardoon2,5

  • 1a Department of Laboratory Medicine , Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences , Karaj , Iran.

Expert Review of Clinical Immunology
|September 17, 2016
PubMed
Summary

Common variable immunodeficiency (CVID) is a primary antibody deficiency causing infections and autoimmunity. Managing autoimmune issues in CVID patients is complex due to immune dysregulation and inflammation.

Keywords:
Common variable immunodeficiencyautoantibodyautoimmunitymanagementprimary antibody deficiency

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Area of Science:

  • Immunology
  • Clinical Medicine

Background:

  • Common variable immunodeficiency (CVID) is a heterogeneous primary immunodeficiency characterized by antibody deficiency.
  • Patients exhibit increased susceptibility to infections and low immunoglobulin levels.
  • Comorbidities include enteropathy, granulomas, malignancy, and autoimmune conditions.

Purpose of the Study:

  • To highlight the challenges in managing autoimmune complications in CVID patients.
  • To emphasize the paradoxical nature of autoimmunity coexisting with immunodeficiency.

Main Methods:

  • Review of existing literature on CVID and associated autoimmune conditions.
  • Analysis of clinical management strategies for autoimmune manifestations in CVID.

Main Results:

  • Autoimmunity is prevalent in CVID, posing diagnostic and therapeutic challenges.
  • Immune dysregulation and chronic inflammation complicate the management of autoimmune diseases in these patients.

Conclusions:

  • Management of autoimmunity in CVID requires specialized approaches.
  • Understanding immune system dysfunction is crucial for effective treatment of autoimmune complications in CVID.