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Updated: Mar 15, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Insights
Gestational substance exposure affects newborns, necessitating screening for acute care and early intervention. This review covers substance use extent, neonatal testing matrices, and legal aspects.
Area of Science:
- Neonatal care
- Pharmacology
- Public health
Background:
- Gestational substance exposure is a significant public health issue.
- Neonates can be exposed to illicit, prescription, and legal substances during pregnancy.
- Exposure can lead to teratogenic effects or neonatal dependence and withdrawal.
Purpose of the Study:
- To review the extent of substance use by pregnant women.
- To provide an overview of neonatal biologic matrices for drug testing.
- To discuss legal implications of neonatal substance screening.
Main Methods:
- Literature review on gestational substance exposure.
- Analysis of neonatal drug testing matrices.
- Discussion of legal frameworks surrounding neonatal screening.
Main Results:
- Substance use during pregnancy poses risks to neonates.
- Various biologic matrices are available for neonatal drug testing.
- Legal considerations are crucial in neonatal substance screening protocols.
Conclusions:
- Newborn screening for gestational substance exposure is vital for optimal outcomes.
- Understanding substance use patterns and testing methods is essential for clinicians.
- Legal and ethical aspects must be addressed in neonatal substance screening policies.
Abstract:
Gestational substance exposure continues to be a significant problem. Neonates may be exposed to various substances including illicit drugs, prescription drugs, and other legal substances that are best not used during pregnancy because of their potential deleterious effects as possible teratogens or their potential to create dependence and thus withdrawal in the neonate. Screening the newborn for gestational substance exposure is important for both acute care and early intervention to promote the best possible long-term outcomes. This column provides insight into what is known about the extent of substance use by pregnant women, an overview of neonatal biologic matrices for drug testing, and a discussion of the legal implications of neonatal substance screening.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pharmacokinetics in Pediatric Patients: Drug Distribution

