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Related Experiment Video

Updated: Mar 15, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Implementing an antimicrobial stewardship program in out-patient dialysis units.

Cheston B Cunha¹, Erika M C D'Agata

¹Division of Infectious Diseases, Brown University, Warren Alpert Medical School, Providence, Rhode Island, USA.

Current Opinion in Nephrology and Hypertension

|September 17, 2016

Summary

Antimicrobial stewardship programs (ASP) are crucial for combating rising multidrug-resistant organisms (MDRO) in chronic hemodialysis patients. Implementing ASP can reduce mortality, adverse events, and costs while improving antimicrobial susceptibility.

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Published on: August 30, 2018

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Area of Science:

Infectious Diseases
Nephrology
Public Health

Background:

Chronic hemodialysis patients face increasing rates of multidrug-resistant organisms (MDRO).
Antimicrobial exposure is a primary driver for MDRO emergence and spread.
A significant percentage of antimicrobial doses in outpatient dialysis units are potentially unnecessary.

Purpose of the Study:

To review the essential components and interventions of antimicrobial stewardship programs (ASP).
To emphasize the importance of ASP in the context of chronic hemodialysis settings.

Main Methods:

Review of existing evidence-based guidelines from professional societies.
Adaptation of recommendations for the outpatient dialysis environment.

Main Results:

Guidelines for ASP development and implementation exist.
Many recommendations are adaptable to outpatient dialysis.

Conclusions:

Implementing ASP in outpatient dialysis settings can decrease mortality and adverse events.
ASP can lead to reduced healthcare costs and improved antimicrobial susceptibility rates.