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Probable Drug-Related Meningioma Detected During the Course of Medication Review Services

Christopher P Alderman1

  • 1University of South Australia, Adelaide, Australia.

The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists
|September 17, 2016
PubMed

Insights

High-dose cyproterone acetate treatment is linked to meningioma development. This case highlights a meningioma in an elderly man with intellectual disability treated with cyproterone for behavioral issues.

Area of Science:

  • Neuro-oncology
  • Endocrinology

Background:

  • Cyproterone acetate (CPA) is an antiandrogen and progestogen medication.
  • Evidence suggests a correlation between high-dose CPA and meningioma formation.
  • Meningiomas are tumors that arise from the meninges, the membranes surrounding the brain and spinal cord.

Observation:

  • A case report of an elderly male patient with intellectual disability is presented.
  • The patient received high-dose cyproterone acetate for problematic sexual behavior.
  • The patient subsequently developed a meningioma.

Findings:

  • The case provides further clinical evidence supporting the association between cyproterone acetate and meningioma.
  • The medication management review highlighted potential risks in long-term CPA users.

Implications:

  • Clinicians should be aware of the meningioma risk associated with high-dose cyproterone acetate, particularly in vulnerable populations.
  • This case underscores the importance of medication reviews in managing potential adverse effects.
  • Further research into the mechanisms and risk factors for CPA-induced meningioma is warranted.

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