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Relationship between serum testosterone and nocturia in men without benign prostate enlargement
1Department of Urology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
Andrology
|September 17, 2016
Summary
In men without enlarged prostates, higher serum testosterone levels were linked to an increased prevalence of nocturia (frequent nighttime urination). However, testosterone did not affect the severity of nocturia symptoms.
Area of Science:
- Urology
- Endocrinology
- Men's Health
Background:
- Nocturia (frequent nighttime urination) is a common condition, particularly in aging men.
- Serum testosterone's role in nocturia is debated, with prior studies often including patients with confounding factors like benign prostatic enlargement (BPE).
- Testosterone is implicated in prostate growth, a known contributor to nocturia.
Purpose of the Study:
- To investigate the relationship between serum total testosterone levels and nocturia in men specifically excluding those with benign prostatic enlargement (BPE).
- To differentiate between the impact of testosterone on nocturia prevalence versus nocturia severity.
Main Methods:
- Retrospective analysis of clinical records from 596 male patients without BPE.
- Evaluation included serum prostate-specific antigen (PSA), serum total testosterone, transrectal ultrasonography, uroflowmetry, International Prostate Symptom Score (IPSS), and International Index of Erectile Function (IIEF).
- Nocturia defined as ≥2 nocturnal voids; severity assessed via IPSS question 7. Multivariate regression analysis controlled for age, IPSS, IIEF, BMI, PSA, prostate volume, and maximal urine flow rate.
Main Results:
- Serum testosterone level was not significantly associated with the severity of nocturia.
- However, nocturia prevalence was significantly positively associated with age, total IPSS, and serum testosterone level (OR=1.150, p=0.041).
- These findings suggest testosterone may play a role in the occurrence, but not the severity, of nocturia in men without BPE.
Conclusions:
- In men without benign prostatic enlargement, serum testosterone levels are positively associated with the prevalence of nocturia.
- Testosterone does not appear to influence the severity of nocturia in this population.
- These findings suggest a potentially opposing role for testosterone in the etiology of nocturia, distinct from its role in prostate growth.
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