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Intraocular Pressure in Premature Low Birth Weight Infants

Sandeep Grover, Zimei Zhou, Shamim Haji

    Journal of Pediatric Ophthalmology and Strabismus
    |September 17, 2016
    PubMed

    Insights

    Intraocular pressure (IOP) and central corneal thickness (CCT) are elevated in premature infants. However, no correlation was found between IOP and CCT in these low birth weight (LBW) infants.

    Area of Science:

    • Ophthalmology
    • Neonatology
    • Pediatrics

    Background:

    • Premature infants, particularly those with low birth weight (LBW), present unique physiological characteristics.
    • Understanding ocular parameters like intraocular pressure (IOP) and central corneal thickness (CCT) is crucial for neonatal eye care.
    • Existing data on IOP and CCT in premature LBW infants is limited, necessitating further investigation.

    Purpose of the Study:

    • To assess intraocular pressure (IOP) and central corneal thickness (CCT) in premature low birth weight (LBW) infants.
    • To determine the correlation between IOP and CCT in this population.
    • To evaluate the relationship between IOP, CCT, and gestational age (GA).

    Main Methods:

    • Evaluated 90 eyes from 45 premature LBW infants (birth weight ≤ 1,500 g or GA ≤ 30 weeks).
    • Measured intraocular pressure (IOP) and central corneal thickness (CCT) in a neonatal intensive care unit.
    • Analyzed data for correlations between IOP, CCT, and gestational age (GA).

    Main Results:

    • Mean GA was 28.2 ± 2.3 weeks and mean birth weight was 1,131.5 ± 380.1 g.
    • Mean IOP was 29.0 ± 9.0 mm Hg and mean CCT was 660.0 ± 65.0 µm.
    • No significant correlation was found between IOP and CCT (r = 0.09; P = .38).
    • A negative correlation was observed between IOP and GA (r = -0.41) and between CCT and GA (r = -0.26).

    Conclusions:

    • Premature infants exhibit higher IOP and thicker CCT compared to adult values.
    • There is no direct correlation between IOP and CCT in premature LBW infants.
    • Gestational age shows a negative correlation with both IOP and CCT in this cohort.
    Abstract

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