Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vascular Spasm01:16

Vascular Spasm

4.5K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
4.5K
Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

4.9K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
4.9K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

5.5K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.5K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

3.8K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.8K
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

553
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
553
Arteries of Lower Limbs01:20

Arteries of Lower Limbs

5.5K
The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol of a randomized controlled trial investigating the effectiveness of Recovery-focused Community support to Avoid readmissions and improve Participation after Stroke (ReCAPS).

International journal of stroke : official journal of the International Stroke Society·2021
Same author

Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration.

Stroke·2021
Same author

Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study.

Neuroepidemiology·2021
Same author

Ischemic Events After Intracerebral Hemorrhage: A New Target for Secondary Prevention.

JAMA neurology·2021
Same author

Secondary Prevention of Stroke: Study Protocol for a Telehealth-Delivered Physical Activity and Diet Pilot Randomized Trial (ENAbLE-Pilot).

Cerebrovascular diseases (Basel, Switzerland)·2021
Same author

Plasma Amyloid-Beta Levels in a Pre-Symptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross-Sectional and Longitudinal Investigation.

International journal of molecular sciences·2021

Related Experiment Video

Updated: Mar 15, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.7K

Stroke.

Graeme J Hankey1

  • 1School of Medicine & Pharmacology, The University of Western Australia, Perth, WA, Australia; Department of Neurology, Sir Charles Gairdner Hospital, Perth, WA, Australia; Western Australian Neuroscience Research Institute (WANRI), Perth, WA, Australia.

Lancet (London, England)
|September 18, 2016
PubMed
Summary
This summary is machine-generated.

Recent stroke advances include endovascular thrombectomy and aspirin for ischemic stroke, plus new anticoagulants and stenting for prevention. Ongoing trials explore treatments for hemorrhagic stroke and brain regeneration therapies.

More Related Videos

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

3.2K
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
08:22

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

15.8K

Related Experiment Videos

Last Updated: Mar 15, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.7K
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

3.2K
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
08:22

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

15.8K

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Regenerative Medicine

Background:

  • Stroke definitions and treatments have significantly evolved over the last decade.
  • While stroke mortality declines, the global burden of stroke continues to rise, necessitating improved prevention strategies.
  • Common risk factors link stroke with other non-communicable diseases, highlighting the need for integrated prevention approaches.

Purpose of the Study:

  • To review recent advancements in the definition, treatment, and prevention of both ischemic and hemorrhagic stroke.
  • To highlight emerging therapeutic strategies for stroke recovery and brain regeneration.
  • To emphasize the need for a comprehensive, integrated approach to primary stroke prevention.

Main Methods:

  • Review of recent clinical trial outcomes and established treatment guidelines for acute stroke management.
  • Analysis of pharmacological, interventional, and regenerative therapies for stroke.
  • Examination of epidemiological trends in stroke incidence and mortality.

Main Results:

  • Endovascular thrombectomy combined with intravenous alteplase improves functional outcomes in acute ischemic stroke.
  • Aspirin demonstrates significant benefits in preventing early recurrent ischemic stroke.
  • Direct oral anticoagulants and carotid stenting offer alternatives for secondary stroke prevention in specific patient populations.
  • Trials are underway for acute intracerebral hemorrhage treatments, including blood pressure management and novel surgical techniques.
  • Pharmacological and stem-cell therapies show promise for brain repair and functional recovery post-stroke.

Conclusions:

  • Significant progress has been made in acute stroke treatment and secondary prevention, improving patient outcomes.
  • Emerging therapies offer new hope for brain regeneration and rehabilitation after stroke.
  • A comprehensive, risk-stratified, and integrated primary prevention strategy is crucial to combat the increasing global burden of stroke.