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Updated: Mar 15, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.8K

Migraine

K R Peck1, Y L Johnson1, T A Smitherman1

  • 1Department of Psychology, University of Mississippi, Oxford, MS, USA.

Handbook of Clinical Neurology
|September 18, 2016
PubMed

Insights

Migraine is a disabling neurologic disorder. Advances in genetics, CGRP antibody development, and psychologic mechanisms offer new insights into migraine pathophysiology and treatment.

Area of Science:

  • Neurology
  • Neuroscience
  • Epidemiology

Background:

  • Migraine is a prevalent, disabling neurologic disorder marked by severe head pain and associated symptoms.
  • Risk factors include comorbid conditions and acute medication overuse.
  • Current understanding of migraine pathophysiology is incomplete.

Purpose of the Study:

  • To provide an overview of migraine epidemiology and mechanisms.
  • To highlight recent advances in understanding migraine pathophysiology.
  • To review clinical trials and discuss future methodologic considerations.

Main Methods:

  • Review of current literature on migraine epidemiology and pathophysiology.
  • Discussion of advances in genetics research (GWAS).
  • Examination of antibody development targeting calcitonin gene-related peptide (CGRP).
  • Exploration of psychologic mechanisms and behavioral interventions.
  • Analysis of clinical trials for pharmacologic and behavioral interventions.

Main Results:

  • Identified risk factors for migraine onset and progression.
  • Highlighted progress in understanding pathophysiologic mechanisms through genetics and CGRP research.
  • Emphasized the role of psychologic factors in treatment efficacy.
  • Reviewed existing clinical trials for interventions and comorbidities.

Conclusions:

  • Advances in genetics, CGRP targeting, and psychologic research are improving the understanding of migraine.
  • Further research and refined clinical trial methodologies are crucial for developing effective migraine treatments.
  • Integrated approaches considering neuroepidemiologic and psychologic mechanisms are promising.
Keywords:
epidemiologyheadachemechanismsmigrainerisk factors

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