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Fankun Zhou1, Chang Feng1, Guangqin Fan1

  • 1Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, China.

Chemosphere
|September 18, 2016
PubMed
Abstract

No abstract available in PubMed .

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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