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Phototherapy and vitamin D.

Asta Juzeniene1, Mantas Grigalavicius1, Marina Juraleviciute1

  • 1Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway.

Clinics in Dermatology
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Summary

Phototherapy can enhance vitamin D levels, potentially improving skin conditions like psoriasis. Further research is needed to explore vitamin D

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Area of Science:

  • Dermatology
  • Endocrinology
  • Photobiology

Background:

  • The skin synthesizes vitamin D and responds to its active metabolite.
  • Vitamin D produced during phototherapy may contribute to positive treatment outcomes for skin diseases.
  • Vitamin D derivatives are used topically or orally, often combined with phototherapy.

Purpose of the Study:

  • To review the use of phototherapy in enhancing vitamin D levels.
  • To examine the application of vitamin D analogues with phototherapy.
  • To assess the efficacy and controversies of combination therapies for skin diseases.

Main Methods:

  • Literature review of studies on phototherapy and vitamin D.
  • Analysis of clinical trials involving vitamin D derivatives and phototherapy.
  • Synthesis of evidence on combination therapy outcomes.

Main Results:

  • Phototherapy can increase vitamin D levels, potentially benefiting skin conditions.
  • Vitamin D shows promise in treating psoriasis, though its exact role is unclear.
  • Further investigation is required for vitamin D's role in vitiligo, atopic dermatitis, and mycosis fungoides.

Conclusions:

  • Vitamin D plays a role in treating psoriasis, with combination therapy showing promise.
  • The therapeutic potential of vitamin D in other dermatological conditions warrants further research.
  • Optimizing phototherapy and vitamin D use requires understanding their interplay in skin health.