Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skeletal disease in primary hyperparathyroidism.

S J Silverberg1, E Shane, L de la Cruz

  • 1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retrospective cohort study of pure tone audiometry hearing changes from ototoxic metals and solvents, continuous noise, and impulse noise exposures at Hill Air Force Base from 2005 to 2019.

Journal of occupational and environmental hygiene·2025
Same author

Baseline Findings of PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE4 Carriers before the Onset of Dementia.

The journal of prevention of Alzheimer's disease·2023
Same author

Correction to: The clinician's guide to prevention and treatment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

The clinician's guide to prevention and treatment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same journal

Ossification of the Posterior Longitudinal Ligament - Novel findings from Pandora's box of ENPP1 Deficiency.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

From loci to cells: mapping variant function in bone and joint diseases.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

The Journal of Bone and Mineral Research (JBMR) 40th anniversary celebration: the fourth decade (Part 2).

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Increased Prevalence of Coronary Artery Calcification in Patients with Post-Surgical Hypoparathyroidism.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Alendronate for 6 or 12 months following denosumab discontinuation in women with postmenopausal osteoporosis: A prospective observational study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Is Zoledronic acid cost-saving in daily practice?

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
See all related articles

Sensitive bone tests reveal cortical bone disease in most primary hyperparathyroidism patients, even without symptoms. Mild hyperparathyroidism may protect cancellous bone.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Radiology

Background:

  • Primary hyperparathyroidism often presents without overt skeletal symptoms.
  • Conventional radiography is insensitive to early bone changes in this condition.

Purpose of the Study:

  • To assess skeletal involvement in primary hyperparathyroidism using advanced techniques.
  • To evaluate bone mineral density and bone biopsy findings in asymptomatic patients.

Main Methods:

  • Investigated 52 patients with mild hypercalcemia and normal phosphorus.
  • Utilized bone densitometry at the radius, lumbar spine, and femoral neck.
  • Performed percutaneous bone biopsy to analyze cortical and cancellous bone structure.

Main Results:

Related Experiment Videos

  • Bone mineral density was significantly reduced at the cortical bone site (radius).
  • Cancellous bone sites (lumbar spine) showed preserved bone mineral density.
  • Bone biopsy confirmed preferential cortical bone loss and preserved cancellous bone volume.

Conclusions:

  • Asymptomatic primary hyperparathyroidism is associated with subclinical cortical bone disease.
  • The condition may offer a protective effect on cancellous bone.
  • Further research is needed to understand the therapeutic implications.