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CCAT1: an oncogenic long noncoding RNA in human cancers
1Department of General Surgery, Wuxi No. 3 People's Hospital, Wuxi, 214002, Jiangsu, China.
Purpose:
Long noncoding RNAs (lncRNAs) are a new class of noncoding RNAs that participate in a variety of biological processes such as cell proliferation, cell cycle, differentiation and apoptosis, mainly by regulation of gene expression at various levels, including chromatin, splicing, transcriptional and post-transcriptional levels. CCAT1 is a recently identified oncogenic lncRNA, which has been reported to be consistently upregulated in multiple cancer tissues and closely correlated with initiation and progression of cancers. The aim of this paper is to provide an overview of various roles of CCAT1 in human cancers.
Methods And Results:
We searched studies in electronic databases. Studies have shown the high expression pattern and oncogenic role of CCAT1 in different types of cancer, and aberrant expression of CCAT1 is involved in several processes correlated with carcinogenesis such as cell proliferation, apoptosis, migration and invasion by regulating different target genes and pathways.
Conclusion:
LncRNA CCAT1 promises to be a novel diagnostic biomarker, therapeutic target, as well as prognostic biomarker in human cancers.
Insights
Long noncoding RNA CCAT1 (CCAT1) is upregulated in cancers and drives tumor growth by affecting cell proliferation and migration. CCAT1 shows potential as a diagnostic and therapeutic target for human cancers.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) regulate gene expression at multiple levels.
- CCAT1 is an oncogenic lncRNA consistently upregulated in various human cancers.
- CCAT1 is linked to cancer initiation and progression.
Purpose of the Study:
- To provide an overview of the diverse roles of CCAT1 in human cancers.
- To summarize the current understanding of CCAT1's function in oncogenesis.
Main Methods:
- Literature review of electronic databases.
- Analysis of studies reporting CCAT1 expression and function in cancer.
Main Results:
- CCAT1 exhibits high expression in diverse cancer types.
- Aberrant CCAT1 expression influences cell proliferation, apoptosis, migration, and invasion.
- CCAT1 regulates multiple target genes and pathways involved in carcinogenesis.
Conclusions:
- LncRNA CCAT1 demonstrates potential as a novel diagnostic biomarker.
- CCAT1 is a promising therapeutic target for cancer treatment.
- CCAT1 may serve as a prognostic biomarker in human cancers.
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