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Related Experiment Video

Updated: Mar 15, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Skeletal sarcoidosis].

J Freyschmidt¹, P Freyschmidt²

¹Beratungsstelle und Referenzzentrum für Osteoradiologie, Klinikum Bremen-Mitte, Oberneulander Landstr. 58, 28355, Bremen, Deutschland. freyschmidt@radiologie-freyschmidt.de.

|September 18, 2016

Summary

This summary is machine-generated.

Skeletal sarcoidosis, affecting 14% of patients, presents as bone lesions or synovitis. Diagnosis relies on imaging and recognizing skin changes, differentiating it from other bone diseases.

Keywords:

Arthralgias Chest computed tomography Magnetic resonance imaging Skeletal involvement Skin manifestations

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Area of Science:

Rheumatology
Orthopedics
Radiology

Background:

Sarcoidosis affects 10-12 per 100,000 individuals annually.
Skeletal involvement occurs in approximately 14% of sarcoidosis cases.
Noncaseating epithelioid cell granulomas are the underlying pathology.

Purpose of the Study:

To detail the etiology, pathology, clinical presentation, radiology, and differential diagnosis of skeletal sarcoidosis.
To enhance understanding of this rare manifestation of sarcoidosis.

Main Methods:

Review of clinical presentations, radiological findings, and diagnostic criteria.
Emphasis on imaging techniques like radiography, CT, MRI, and PET.
Discussion of differential diagnoses including tuberculosis, metastases, and myeloma.

Main Results:

Skeletal sarcoidosis can manifest as osteolysis, osteosclerosis, or synovitis.
Lesions are often asymptomatic and predominantly affect the hands and axial skeleton.
Radiography and CT are key for visualizing bone destruction, while MRI/PET detect marrow involvement.

Conclusions:

Skeletal sarcoidosis diagnosis requires integrating clinical, radiological, and dermatological findings.
Thorax imaging and dermatological assessment are crucial for differentiation.
Early and accurate diagnosis is essential for appropriate management.