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Risk Factors of Acute Pancreatitis in Oral Double Balloon Enteroscopy
Marcela Kopáčová1, Jan Bureš2, Stanislav Rejchrt2
12nd Department of Medicine - Gastroenterology, Charles University, Faculty of Medicine in Hradec Králové, University Teaching Hospital, Hradec Králové, Czech Republic. marcela.kopacova@fnhk.cz.
Acta Medica (Hradec Kralove)
|September 18, 2016
Summary
This study found no reliable lab markers to predict acute pancreatitis risk after double balloon enteroscopy (DBE). Hyperamylasemia is common post-DBE, likely due to mechanical strain, but doesn't predict pancreatitis.
Area of Science:
- Gastroenterology
- Endoscopy
- Pancreatology
Background:
- Double balloon enteroscopy (DBE) is a valuable diagnostic tool, but acute pancreatitis is a rare but serious complication.
- Hyperamylasemia is frequently observed post-DBE, suggesting mechanical pancreatic strain, but its predictive value for pancreatitis is unclear.
Purpose of the Study:
- To identify predictive laboratory markers for acute pancreatitis following diagnostic DBE.
- To investigate changes in various serum markers before and after DBE procedures.
Main Methods:
- Prospective investigation of laboratory markers including serum amylase, lipase, cathepsin B, procalcitonin, and others before and 4 hours after DBE.
- Correlation analysis between pre- and post-DBE marker levels and clinical outcomes.
Main Results:
- Serum amylase and lipase levels significantly increased up to 4 hours post-DBE.
- Serum cathepsin B and procalcitonin levels significantly decreased post-DBE compared to baseline and controls.
- No pre-procedural laboratory markers were found to be determinative in predicting higher risk of acute pancreatitis after DBE.
Conclusions:
- Hyperamylasemia post-DBE is common but does not appear to predict acute pancreatitis.
- Currently, no laboratory markers can reliably identify patients at higher risk for acute pancreatitis following DBE.
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