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Application of MoS2 modified screen-printed electrodes for highly sensitive detection of bovine serum albumin
Manil Kukkar1, Ashish Sharma2, Parveen Kumar3
1Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30-C, Chandigarh, 160030, India; Academy of Scientific and Innovative Research, CSIR-CSIO, Sector 30-C, Chandigarh, 160030, India.
Abstract:
The present work reports the application of a new molybdenum disulphide (MoS2)-based electrochemical platform for highly sensitive quantitation of an iron-binding protein, bovine serum albumin (BSA). The gold screen-printed electrodes were modified with MoS2 nanoflakes, followed by bioconjugation with anti-BSA antibodies. Using the above bioelectrode, cyclic voltammetric analysis was carried out in the presence of a Fe(3+)/Fe(2+) redox probe which exhibited a linear response of peak current with varying concentrations of BSA up to 10 ng/mL (with a detection limit of 0.006 ng/mL). This study is novel in that it shows a considerable enhancement of signal during electrochemical sensing of a protein.
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