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Published on: March 14, 2019
Identification of Circulating MiR-25 as a Potential Biomarker for Pancreatic Cancer Diagnosis
Ting Deng1, Yaozong Yuan, Chunni Zhang
1Department of Gastrointestinal Medical Oncology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer; Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin, China.
Background:
The aim of this study was to identify novel microRNAs for potential use in the diagnosis of pancreatic cancer (PaC).
Methods:
A total of 1063 serum samples from 303 patients with PaC were collected, and the expression level of miR-25 was measured using quantitative real-time PCR (qRT-PCR).
Results:
We found that miR-25 had significant diagnostic value for the differential diagnosis of PaC in normal controls with an AUC (the area under the ROC curve) of 0.915 (95% CI: 0.893-0.937) that was significantly higher compared with an AUC of 0.725 for serum tumor marker carcinoembryonic antigen (CEA) and an AUC of 0.844 for CA19-9.
Conclusions:
These data suggest that serum miR-25 has strong potential as a novel biomarker for the early detection of PaC.
