Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
T Cell Types and Functions01:24

T Cell Types and Functions

3.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.1K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.0K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

596
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
596
What is the Immune System?01:38

What is the Immune System?

142.3K
Overview
142.3K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.7K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Organ Involvement and Treatment Response across Cutaneous Sarcoidosis Subtypes.

Acta dermato-venereologica·2026
Same author

S1 Guideline: Therapy of generalized pustular psoriasis.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

[Tzanck test-still relevant?]

Dermatologie (Heidelberg, Germany)·2026
Same author

[Iodine provocation test].

Dermatologie (Heidelberg, Germany)·2026
Same author

Summary of Research: Apremilast Improves Skin Outcomes in Pediatric Plaque Psoriasis of Shorter Disease Duration: 52-Week Results from the SPROUT Phase 3 Trial.

Dermatology and therapy·2026
Same author

S3 guideline diagnostics and therapy in alopecia areata - Part 2: Therapy, psychosocial and cosmetic support.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Decoding gut microbiome alterations in celiac disease: Implications for pathogenesis and treatment.

Autoimmunity reviews·2026
Same journal

Rethinking immunosuppression in limited cutaneous systemic sclerosis. The lcSSc conundrum; pros and cons for a timely immunosuppressive treatment.

Autoimmunity reviews·2026
Same journal

Kidney failure in patients with ANCA-associated vasculitis: A systematic review of outcomes.

Autoimmunity reviews·2026
Same journal

The role of antimicrobial peptides in rheumatoid arthritis: From mucosal predisposition to chronic synovitis.

Autoimmunity reviews·2026
Same journal

The role of short-chain fatty acids as key mediators of gut microbiota - host crosstalk in thyroid diseases.

Autoimmunity reviews·2026
Same journal

Intermittent hydrarthrosis (periodic synoviosis): A narrative review.

Autoimmunity reviews·2026
See all related articles

Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

993

Psoriasis and autoimmunity.

Michael Sticherling1

  • 1Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-NĂĽrnberg, Erlangen, Germany, Ulmenweg 18, D-91054 Erlangen, Germany.

Autoimmunity Reviews
|September 19, 2016
PubMed
Summary
This summary is machine-generated.

Psoriasis, a chronic inflammatory skin disease, may involve autoimmune mechanisms, complicating its exact cause. Understanding this link could offer new antigen-specific treatment options for psoriasis patients.

Keywords:
AutoantigensAutoimmunityInnate immunityPsoriasis

More Related Videos

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.3K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

6.0K

Related Experiment Videos

Last Updated: Mar 15, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

993
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.3K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

6.0K

Area of Science:

  • Immunodermatology
  • Autoimmunity research
  • Chronic inflammatory diseases

Background:

  • Psoriasis is a prevalent chronic inflammatory skin condition with incompletely understood etiology.
  • Clinical presentation suggests overlap with inflammatory and autoimmune disorders.
  • The role of autoantigens and specific autoantibodies in psoriasis pathogenesis is under investigation.

Purpose of the Study:

  • To explore the potential autoimmune basis of psoriasis.
  • To differentiate between autoinflammation and autoimmunity in psoriasis.
  • To identify potential targets for novel therapeutic strategies.

Main Methods:

  • Review of current literature on psoriasis pathogenesis.
  • Analysis of serological findings in psoriasis patients.
  • Comparison of pathogenic mechanisms with other autoimmune diseases.

Main Results:

  • Psoriasis exhibits characteristics of both autoinflammation and autoimmunity.
  • Association between psoriasis and other autoimmune diseases is noted.
  • Circulating autoantibodies have been detected in psoriasis patients.

Conclusions:

  • The precise pathogenic mechanisms of psoriasis remain elusive, with ongoing debate regarding its autoimmune nature.
  • Psoriasis may represent a complex interplay between autoinflammatory and autoimmune processes.
  • Identifying autoimmune components could expand therapeutic options beyond current T-cell targeted treatments.