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Cognitive disorders and antiphospholipid antibodies
Cécile M Yelnik1, Elizabeth Kozora2, Simone Appenzeller3
1Internal Medicine Department, University of Lille, UFR Medicine, Lille, France.
Autoimmunity Reviews
|September 19, 2016
Summary
Antiphospholipid antibodies (aPL) are linked to cognitive disorders in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE), but the exact relationship and mechanisms require further research. This review synthesizes current knowledge on cognitive dysfunction in aPL carriers.
Area of Science:
- Rheumatology
- Neurology
- Immunology
Background:
- Cognitive disorders are common in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE).
- The precise relationship between antiphospholipid antibodies (aPL) and cognitive impairment is complex and not fully understood.
- Existing literature is complicated by disease overlap, small study sizes, and varied diagnostic criteria.
Purpose of the Study:
- To review and synthesize current knowledge on cognitive dysfunction associated with aPL.
- To analyze epidemiologic, clinical, and imaging data related to aPL-associated cognitive impairment.
- To summarize treatment strategies for cognitive dysfunction in aPL-positive individuals.
Main Methods:
- Literature review of studies on cognitive disorders in APS and SLE.
- Analysis of data stratified by aPL status: carriers without APS, APS without autoimmune overlap, and SLE with aPL.
- Inclusion of epidemiologic, clinical, imaging, and treatment data.
Main Results:
- Cognitive dysfunction is a recognized neurological manifestation in APS and SLE patients.
- Multiple mechanisms may contribute to aPL-related cognitive impairment.
- Data synthesis highlights the need for standardized diagnostic approaches.
Conclusions:
- Cognitive dysfunction is a significant concern in individuals with antiphospholipid antibodies.
- Further research is needed to elucidate the underlying mechanisms and optimize treatment.
- Standardized diagnostic criteria are crucial for accurate assessment and management.
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