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Pregnancy loss in a small chorionic villus sampling series
B A Clark1, J M Bissonnette, S B Olson
1Department of Obstetrics and Gynecology, Oregon Health Sciences University, Portland 97201.
American Journal of Obstetrics and Gynecology
|August 1, 1989
Summary
Early chorionic villus sampling (CVS) does not show a high pregnancy loss rate. This study
Area of Science:
- Obstetrics and Gynecology
- Prenatal Diagnostics
Background:
- Previous studies suggested high pregnancy loss rates with early chorionic villus biopsy.
- Concerns existed regarding the safety of chorionic villus sampling (CVS) in early pregnancy.
Purpose of the Study:
- To evaluate the pregnancy loss rate associated with chorionic villus biopsy in the initial cases.
- To determine if early CVS poses a higher risk of fetal loss compared to previous reports.
Main Methods:
- Retrospective analysis of pregnancy outcomes.
- Inclusion of 211 cases undergoing chorionic villus biopsy.
Main Results:
- The total pregnancy loss rate in the initial 211 cases was 7.1%.
- Pregnancy losses not attributed to induced abortion or cytogenetic abnormality were 2.8%.
Conclusions:
- The findings do not support previous contentions of a high pregnancy loss rate with early chorionic villus biopsy.
- Early chorionic villus sampling appears to have an acceptable safety profile regarding pregnancy loss.