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Related Experiment Videos

Normal amniotic fluid volume changes throughout pregnancy.

R A Brace1, E J Wolf

  • 1Department of Reproductive Medicine, University of California, San Diego, La Jolla 92093.

American Journal of Obstetrics and Gynecology
|August 1, 1989
PubMed
Summary
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Amniotic fluid volume in normal pregnancies shows consistent variability throughout gestation. Mean amniotic fluid volume remains stable between 22 and 39 weeks, averaging 777 ml.

Area of Science:

  • Obstetrics and Gynecology
  • Fetal Medicine
  • Reproductive Biology

Background:

  • Amniotic fluid volume is crucial for fetal development and well-being.
  • Understanding normal amniotic fluid volume changes throughout pregnancy is essential for clinical assessment.

Purpose of the Study:

  • To quantitatively characterize changes in amniotic fluid volume during gestation.
  • To establish reference ranges for amniotic fluid volume across different gestational ages.

Main Methods:

  • Analysis of 705 published amniotic fluid volume data points from normal pregnancies.
  • Log transformation of data to assess variability.
  • Calculation of 95% confidence intervals for mean amniotic fluid volume.

Main Results:

Related Experiment Videos

  • Uniform variability of amniotic fluid volume observed from 8 to 43 weeks' gestation after log transformation.
  • Mean amniotic fluid volume did not significantly change between 22 and 39 weeks, averaging 777 ml.
  • The 95% confidence interval for mean amniotic fluid volume ranged from 302 to 1997 ml.

Conclusions:

  • Amniotic fluid volume exhibits consistent relative variability throughout normal gestation.
  • A stable mean amniotic fluid volume exists between 22 and 39 weeks, challenging previous assumptions.
  • The study provides valuable nomograms for assessing amniotic fluid volume in clinical practice.