Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bronchial epithelial cells release chemoattractant activity for monocytes.

S Koyama1, S I Rennard, S Shoji

  • 1Research Service, Omaha Veterans Administration Medical Center, Nebraska 68105.

The American Journal of Physiology
|August 1, 1989
PubMed
Summary

Bronchial epithelial cells release factors that attract monocytes, the precursors to lung macrophages. This suggests epithelial cells play a key role in initiating immune responses within the airways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling Intrinsic Triplet Superconductivity in Noncentrosymmetric NbRe through Inverse Spin-Valve Effects.

Physical review letters·2025
Same author

Use of levetiracetam for the successful treatment of suspected myoclonic seizures: five dogs (2016-2022).

The Journal of small animal practice·2024
Same author

Lipid droplets and perilipins in canine osteosarcoma. Investigations on tumor tissue, 2D and 3D cell culture models.

Veterinary research communications·2022
Same author

Soybean Phosphatides and Blood Lipids of Primates <sup>1</sup>.

Journal of food protection·2019
Same author

Differences in intestinal size, structure, and function contributing to feed efficiency in broiler chickens reared at geographically distant locations.

Poultry science·2017
Same author

Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease.

Acta neurologica Scandinavica·2017

Area of Science:

  • Immunology
  • Cell Biology
  • Respiratory Medicine

Background:

  • Lung macrophages are crucial for local immunity.
  • Bronchial epithelial cells influence the airway cellular environment.
  • Chemotactic factors attract specific immune cells.

Purpose of the Study:

  • To investigate if bronchial epithelial cells release chemotactic activity for monocytes.
  • To understand the role of epithelial cells in monocyte recruitment to the airways.

Main Methods:

  • Bovine bronchial epithelial cells were cultured.
  • Supernatant fluids were collected at various time points (12-120 h).
  • Monocyte chemotactic activity was assessed using a blind-well chamber technique.

Related Experiment Videos

Main Results:

  • Supernatant fluids showed significantly higher monocyte chemotactic activity compared to control medium.
  • Optimal chemotactic activity was observed in supernatants harvested at 72 hours.
  • Both low-molecular-weight lipid-soluble and high-molecular-weight protein factors were identified.

Conclusions:

  • Bronchial epithelial cells actively recruit monocytes into the bronchial passages.
  • Epithelial-derived factors modulate the local immune response in the lungs.
  • This mechanism is vital for initiating and regulating airway immunity.