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Related Experiment Videos

Immunologic dysfunction in the myeloproliferative disorders.

N J DiBella, G L Brown

    Cancer
    |July 1, 1978
    PubMed
    Summary

    Patients with myeloproliferative disorders often show abnormal cellular immune responses in vitro, particularly reduced lymphocyte reactivity to mitogens. However, their in vivo delayed hypersensitivity and humoral immunity remain largely unaffected.

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    The Journal of experimental medicine·2009

    Area of Science:

    • Immunology
    • Hematology
    • Oncology

    Background:

    • Myeloproliferative disorders (MPDs) are a group of clonal hematopoietic stem cell diseases.
    • Immune dysregulation is a recognized feature of MPDs, but its extent and specific manifestations require further elucidation.

    Purpose of the Study:

    • To investigate the immunological status of patients with various myeloproliferative disorders.
    • To assess cellular and humoral immune responses in MPD patients.

    Main Methods:

    • Immunological evaluation of 40 MPD patients.
    • Measurement of serum immunoglobulin and C'3 levels.
    • Assessment of peripheral blood lymphocyte response to phytohemagglutinin and pokeweed mitogen.
    • Intradermal skin testing for anergy.

    Main Results:

    • Most patients had normal serum immunoglobulin levels; no monoclonal gammopathies were detected.
    • Decreased serum C'3 levels were observed in 48% of patients.
    • Reduced lymphocyte responses to phytohemagglutinin (65%) and pokeweed mitogen (64%) were common, with polycythemia vera patients showing the least impairment.
    • Despite diminished in vitro responses, only 6% of patients were anergic to skin testing.

    Conclusions:

    • Patients with myeloproliferative disorders exhibit significant in vitro cellular immune abnormalities, including decreased mitogenic responses.
    • In vivo cellular immunity (delayed hypersensitivity) and humoral immunity appear minimally affected in most MPD patients.
    • Chemotherapy may influence lymphocyte responses, particularly in chronic myelogenous leukemia.

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